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Tofranil and Valdecoxib

Determining the interaction of Tofranil and Valdecoxib and the possibility of their joint administration.

Check result:

Tofranil <> Valdecoxib

Relevance: 11.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Valdecoxib may decrease the metabolism of some drugs that are substrates of CYP450 2C19. The therapeutic effect of these drugs may be increased. Valdecoxib appears to be a weak inhibitor of CYP450 2C19 hepatic isoenzymes. The clinical significance is unknown. Parecoxib, a prodrug of valdecoxib, may also interact. Monitoring for altered efficacy and safety is advisable during concurrent therapy.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Tofranil

Generic Name: imipramine

Brand name: Tofranil, Tofranil-PM

Synonyms: n.a.

What is Tofranil?

Valdecoxib

Generic Name: valdecoxib

Brand name:

Synonyms: Valdecoxib (Oral)

What is Valdecoxib?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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