Tolbutamide and Xiaflex

• Generic Name: tolbutamide
• Dosage Forms: n.a.
• Other Brand Names:

  Orinase, Orinase Diagnostic, Tol-Tab

Tolbutamide causes the pancreas to produce insulin and increases your body's response to it.

Tolbutamide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Tolbutamide is not for treating type 1 diabetes.

Tolbutamide may also be used for purposes not listed in this medication guide.

• Generic Name: collagenase clostridium histolyticum
• Dosage Forms: injection
• Other Brand Names: Xiaflex

Xiaflex (collagenase clostridium histolyticum) is made from a mixture of proteins derived from a certain bacteria.

Xiaflex is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.

Xiaflex is also used to treat a related condition called Peyronie's disease in adult men. This condition causes scar tissue or "plaque" to develop under the skin of the penis, resulting in an abnormal curving of the penis during erection.

Xiaflex is available for Peyronie's disease only from a certified pharmacy under a special program called Xiaflex REMS. You must be registered in the program and understand the risks of taking this medicine.