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Tolcapone and Twinject

Determining the interaction of Tolcapone and Twinject and the possibility of their joint administration.

Check result:

Tolcapone <> Twinject

Relevance: 11.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using EPINEPHrine together with tolcapone may increase your heart rate and blood pressure, and affect the rhythm of your heart . Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: COMT inhibitors affect the elimination of drugs metabolized by catechol-O-methyltransferase (COMT) and may potentiate their effects. Arrhythmias, increased heart rate, and blood pressure changes may occur. Entacapone has increased heart rates up to 80% when coadministered with isoproterenol and epinephrine. Ventricular tachycardia has also been reported.

MANAGEMENT: The manufacturer recommends that caution be exercised when these drugs are given together. Monitoring for changes in hemodynamic status and ECG is recommended.

References

"Product Information. Tasmar (tolcapone)." Valeant Pharmaceuticals, Costa Mesa, CA.
"Product Information. Comtan (entacapone)" Novartis Pharmaceuticals, East Hanover, NJ.
Illi A, Sundberg S, Ojala-Karlsson P, Korhonen P, Scheinin M, Gordin A "The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine." Clin Pharmacol Ther 58 (1995): 221-7

Tolcapone

Generic Name: tolcapone

Brand name: Tasmar

Synonyms: n.a.

What is Tolcapone?

Twinject

Generic Name: epinephrine

Brand name: EpiPen, Symjepi, Twinject, Adrenalin, Auvi-Q, Epinephrinesnap-EMS, EpiPen 2-Pak, EpiPen JR 2-Pak, EPIsnap, Auvi-Q Auto-injector, Primatene Mist Inhaler, Adrenaclick, Primatene Mist

Synonyms: Twinject Auto-Injector

What is Twinject?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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