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Topamax and Zovia 1/50e

Determining the interaction of Topamax and Zovia 1/50e and the possibility of their joint administration.

Check result:

Topamax <> Zovia 1/50e

Relevance: 07.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ethinyl estradiol together with topiramate can alter the effects of ethinyl estradiol. Topiramate can make birth control pills less effective, which may result in pregnancy. Before taking topiramate, tell your doctor if you use birth control pills. If you are using oral contraceptives you should be advised of the risk of breakthrough bleeding and unintended pregnancy during topiramate therapy. Alternative or additional methods of birth control should be considered during topiramate therapy. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADDITIONAL CONTRACEPTION RECOMMENDED: Efficacy of oral contraception may be decreased by concomitant use with topiramate. The mechanism appears to be increased metabolism of the estrogenic component of the oral contraceptive. In a pharmacokinetic study with topiramate 800 mg/day, ethinyl estradiol clearance increased by 47% (range 13% to 107%), while norethindrone was unaffected. Although this has not been reported with mestranol, the likelihood of an interaction should be considered.

MANAGEMENT: Patients taking oral contraceptives and topiramate should be warned of the potential for decreased efficacy of the oral birth control, counseled about the use of additional pregnancy prevention methods, and advised to report any changes in bleeding patterns to their clinician. Some experts have recommended a higher dose contraceptive; however, no specific recommendations are available. Intrauterine systems are unlikely to be significantly affected because of their local action.

References

Wilbur K, Ensom MHH "Pharmacokinetic drug interactions between oral contraceptives and second-generation anticonvulsants." Clin Pharmacokinet 38 (2000): 355-65
"FFPRHC Guidance (April 2005). Drug interactions with hormonal contraception." J Fam Plann Reprod Health Care 31 (2005): 139-51
"Product Information. Topamax (topiramate)." Ortho Pharmaceutical Corporation, Raritan, NJ.
Rosenfeld WE, Doose DR, Walker SA, Nayak RK "Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients wit epilepsy." Epilepsia 38 (1997): 317-23

Topamax

Generic Name: topiramate

Brand name: Qudexy XR, Topamax, Topamax Sprinkle, Topiragen, Trokendi XR, Qudexy XR Sprinkle

Synonyms: n.a.

What is Topamax?

Zovia 1/50e

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/50, Zovia 1/50E

What is Zovia 1/50e?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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