Topcare Sleep Aid and Zyvox

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using doxylamine together with linezolid. Combining these medications may increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. You should contact your doctor immediately if you experience these symptoms. Other side effects may also increase, such as drowsiness, dry mouth, difficulty urinating, abdominal cramping, constipation, palpitation, confusion, and memory problems. In general, it is advisable to wait at least 14 days after you stop using linezolid or similar medications before you start using doxylamine. You should avoid or limit the use of alcohol during treatment with doxylamine. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Monoamine oxidase inhibitors (MAOIs) may prolong or intensify the anticholinergic and CNS-depressant effects of doxylamine. In addition, concomitant use may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucination, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: The use of doxylamine in combination with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine) is considered contraindicated. At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with doxylamine.

Topcare Sleep Aid

Generic Name: doxylamine

Brand name: Nitetime Sleep-Aid, Sleep Aid, Unisom, Nytol Maximum Strength, Aldex AN

Synonyms: Sleep Aid, Good Neighbor Sleep Aid

What is Topcare Sleep Aid?

Zyvox

Generic Name: linezolid

Brand name: Zyvox

Synonyms: n.a.

What is Zyvox?