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Tramadol Tablets and Zyvox

Determining the interaction of Tramadol Tablets and Zyvox and the possibility of their joint administration.

Check result:

Tramadol Tablets <> Zyvox

Relevance: 01.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using linezolid together with traMADol is not recommended. Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm or stiffness, tremor, stomach cramp, nausea, vomiting, and diarrhea. In general, you should wait at least 14 days after stopping linezolid before you start treatment with traMADol. Similarly, you should wait at least 7 to 14 days after stopping traMADol before starting linezolid. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Monoamine oxidase inhibitors (MAOIs) may potentiate the serotonergic activity of tramadol and increase the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5HT1A receptors. The mechanism is an additive pharmacodynamic effect resulting from MAOI inhibition of serotonin metabolism. Patients receiving this combination of drugs may also experience an increased risk of seizures due to lowering of seizure threshold.

MANAGEMENT: Concurrent use of tramadol and MAOIs or other agents that possess MAOI activity (e.g., furazolidone, procarbazine) is considered contraindicated. At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with tramadol.

References

Mason BJ, Blackburn KH "Possible serotonin syndrome associated with tramadol and sertraline coadministration." Ann Pharmacother 31 (1997): 175-7
Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6
Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13
Egberts AC, ter Borg J, Brodie-Meijer CC "Serotonin syndrome attributed to tramadol addition to paroxetine therapy." Int Clin Psychopharmacol 12 (1997): 181-2
"Product Information. Ultram (tramadol)." McNeil Pharmaceutical, Raritan, NJ.
Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763
"Product Information. Eldepryl (selegiline)." Somerset Pharmaceuticals Inc, Tampa, FL.
Chan BSH, Graudins A, Whyte IM, Dawson AH, Braitberg G, Duggin GG "Serotonin syndrome resulting from drug interactions." Med J Aust 169 (1998): 523-5
Gillman PK "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity." Br J Anaesth (2005):

Tramadol Tablets

Generic Name: tramadol

Brand name: ConZip, Ultram, Ultram ER, Rybix ODT, Ryzolt

Synonyms: Tramadol, TraMADol

What is Tramadol Tablets?

Zyvox

Generic Name: linezolid

Brand name: Zyvox

Synonyms: n.a.

What is Zyvox?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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