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Tranexamic acid Intravenous and Tretinoin Capsules

Determining the interaction of Tranexamic acid Intravenous and Tretinoin Capsules and the possibility of their joint administration.

Check result:
Tranexamic acid Intravenous <> Tretinoin Capsules
Relevance: 28.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using tretinoin together with tranexamic acid. Combining these medications may increase the risk of blood clots, which can lead to serious conditions such as stroke, heart attack, heart failure, collapse, and kidney failure. The risk is greatest during the first month of treatment with tretinoin. You should seek immediate medical attention if you experience potential signs and symptoms of blood clots such as chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: Coadministration of tretinoin (all-trans retinoic acid) with antifibrinolytic agents may increase the risk of thrombosis. Tretinoin is associated with a risk of both venous and arterial thrombosis during the first month of treatment that may involve any organ system. Cases of fatal thrombotic complications have been reported rarely in patients concomitantly treated with tretinoin and antifibrinolytic agents.

MANAGEMENT: Caution is advised when tretinoin is prescribed in combination with antifibrinolytic agents such as aminocaproic acid, aprotinin, or tranexamic acid. Patients should be advised to seek medical attention immediately if they experience potential signs and symptoms of blood clots such as chest pain, shortness of breath, hemoptysis, hematuria, sudden loss of vision, and pain, redness or swelling in an extremity.

References
  • "Product Information. LYSTEDA (tranexamic acid)." Xanodyne Pharmaceuticals Inc, Newport, KY.
  • Hashimoto S, Koike T, Tatewaki W, et al. "Fatal thromboembolism in acute promyelocytic leukemia during all-trans retinoic acid therapy combined with antifibrinolytic therapy for prophylaxis of hemorrhage." Leukemia 8 (1994): 1113-5
  • "Product Information. Vesanoid (tretinoin)." Roche Laboratories, Nutley, NJ.
Tranexamic acid Intravenous

Generic Name: tranexamic acid

Brand name: Cyklokapron, Lysteda

Synonyms: Tranexamic acid, Tranexamic Acid

Tretinoin Capsules

Generic Name: tretinoin

Brand name: Vesanoid

Synonyms: Tretinoin, Tretinoin (Systemic)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle