Tranylcypromine Sulfate and Zarxio

• Generic Name: tranylcypromine
• Dosage Forms: n.a.
• Other Brand Names: Parnate

Treatment of major depressive disorder without melancholia.

Efficacy in major depressive disorder with melancholia (endogenous features) not established.

MAO inhibitors appear particularly effective in treatment of major depressive disorder with atypical features, although other antidepressants (e.g., SSRIs) may initially be used because of their more favorable adverse effect profile.

Because of potential for serious adverse effects and necessity of dietary restrictions, MAO inhibitors (e.g., phenelzine, tranylcypromine) generally are not used as initial therapy for major depressive disorder, but are reserved for carefully selected patients who can be closely supervised and who have depression refractory to other antidepressants (e.g., SSRIs, SNRIs, TCAs) or in whom other therapies are contraindicated.

• Generic Name: filgrastim
• Dosage Forms: injection, solution
• Other Brand Names: Neupogen, Neupogen SingleJect, Nivestym, Zarxio

Zarxio is a man-made form of granulocyte colony-stimulating factor (G-CSF). G-CSF is a substance produced by the body. It stimulates the growth of neutrophils, a type of white blood cell important in the body’s fight against infection.

Do not use this medicine if you have had a serious allergic reaction to human G-CSFs such as filgrastim or pegfilgrastim products.

Before you start treatment, tell your doctor about all of your medical conditions, including if you:

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.