Triaminic Long Acting Cough and Valdecoxib
Determining the interaction of Triaminic Long Acting Cough and Valdecoxib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:According to the manufacturer, the coadministration with valdecoxib 40 mg twice a day for 7 days has been shown to significantly increase the plasma concentrations of dextromethorphan. The proposed mechanism is decreased clearance of dextromethorphan due to inhibition of the CYP450 2D6 enzymatic pathway by valdecoxib at high dosages. However, the dextromethorphan levels reported were still almost 5-fold lower than those observed in CYP450 2D6 poor metabolizers. No particular intervention should be necessary when valdecoxib is administered under normal circumstances with dextromethorphan. At unusually high dosages of valdecoxib, there may be a theoretical risk of increased adverse effects of dextromethorphan such as drowsiness, dizziness, excitation, mental confusion, and respiratory depression. Parecoxib, a prodrug of valdecoxib, may also interact.
- "Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.
Generic Name: dextromethorphan
Brand name: Triaminic Long Acting Cough, Babee Cof, Buckleys Mixture, Creomulsion, DayQuil Cough, Delsym, Robafen Cough Liquidgels, Scot-Tussin Diabetic, Silphen DM, Benylin DM Pediatric, Creo-Terpin, Delsym 12 Hour Cough Relief, Elixsure Cough, Robitussin CoughGels, St. Joseph Cough Suppressant, Sucrets DM Cough, Theraflu Thin Strips Cough, DexAlone, Hold, Sucrets 4-Hour Cough Drops, Robitussin Maximum Strength, Vicks Formula 44
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Triaminic Long Acting Cough-Valerian
- Triaminic Long Acting Cough-Valerian Root
- Triaminic Long Acting Cough-Valganciclovir
- Triaminic Long Acting Cough-Valganciclovir Hydrochloride
- Triaminic Long Acting Cough-Valganciclovir Oral Solution
- Triaminic Long Acting Cough-Valganciclovir Solution
- Valdecoxib-Triaminic Multi-Symptom Fever
- Valdecoxib-Triaminic Night Time Cold & Cough
- Valdecoxib-Triaminic Softchew Throat Pain and Cough
- Valdecoxib-Triaminic Softchews Allergy Congestion
- Valdecoxib-Triaminic Softchews Allergy Sinus
- Valdecoxib-Triaminic Softchews Chest Congestion