Tricitrasol and Tylenol NightTime Cold & Flu
Determining the interaction of Tricitrasol and Tylenol NightTime Cold & Flu and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using pseudoephedrine together with sodium citrate may increase the effects of pseudoephedrine. Contact your doctor if you experience tremor, anxiety, insomnia, irritability, or nervousness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Alkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine, pseudoephedrine, and related drugs. According to one report, an increase in pH from 5.1 to 7.1 increased the half-life of pseudoephedrine from 5 to 16 hours. Toxicity from long-term use of pseudoephedrine has been demonstrated in patients with persistently alkaline urine.
MANAGEMENT: Patients should be monitored for toxic effects such as tremor, anxiety, insomnia, irritability, or nervousness. Dosage reductions may be required.
- Kuntzman RG, Tsai I, Brand L, Mark LC "The influence of urinary pH on the plasma half-life of pseudoephedrine in man and dog and a sensitive assay for its determination in human plasma." Clin Pharmacol Ther 12 (1971): 62-7
- Brater DC, Kaojarern S, Benet LZ, et al "Renal excretion of pseudoephedrine." Clin Pharmacol Ther 28 (1980): 690-4
- Wilkinson GR, Beckett AH "Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47
Generic Name: acetaminophen / dextromethorphan / doxylamine / pseudoephedrine
Brand name: NyQuil D, Nyquil Hot Therapy, All-Nite Cold, Nyquil Cold Medicine, Nyquil Liquicap, Robitussin Night Cold, Tylenol Flu Night Time, Alka-Seltzer Plus Night Time Cold Liquigel, Tylenol Severe Cold & Flu Night Time, Night Time, Theraflu Nighttime Severe Cold, All-Nite Multi-Symptom Cold/Flu Relief, Multi-Symptom Nighttime, NyCair
Synonyms: Acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Tricitrasol-Tylenol PM
- Tricitrasol-Tylenol Severe Allergy
- Tricitrasol-Tylenol Sinus Congestion and Pain
- Tricitrasol-Tylenol Sinus Congestion Nighttime
- Tricitrasol-Tylenol Sinus Congestion/Pain (Acetaminophen and Phenylephrine Tablets)
- Tricitrasol-Tylenol Sinus Congestion/Pain (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)
- Tylenol NightTime Cold & Flu-Tricitrates
- Tylenol NightTime Cold & Flu-Triclabendazole
- Tylenol NightTime Cold & Flu-Tricode AR
- Tylenol NightTime Cold & Flu-Tricode GF
- Tylenol NightTime Cold & Flu-Tricodene SF
- Tylenol NightTime Cold & Flu-Tricon