Trientine and Zinc Gluconate Capsules and Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

When used concomitantly with copper-chelating agents for the treatment of Wilson's disease, zinc salts can compete with copper for chelation and renal excretion. The clinical significance is unknown, although reduced efficacy of one or both agents may theoretically occur. Zinc alone can reduce copper levels by blocking its absorption in the intestine and promoting fecal copper excretion. A small study found that adding penicillamine (1 gm/day) or trientine (1 gm/day) to zinc therapy reduced fecal copper excretion but increased urinary excretion, with the overall copper balance not appreciably changed compared to during zinc therapy alone. In the study, the chelating agent and zinc were given one hour apart. It is not known if simultaneous administration would result in more clinically significant alterations. Other studies have reported on the effectiveness of combination therapy in some patients. However, no data are available to demonstrate that zinc should be added to other drugs used for the treatment of Wilson's disease.

Trientine

Generic Name: trientine

Brand name: Syprine, Clovique

Synonyms: n.a.

What is Trientine?

Zinc Gluconate Capsules and Tablets

Generic Name: zinc gluconate

Brand name: Orazinc, Orazinc 110

Synonyms: Zinc gluconate, Zinc Gluconate

What is Zinc Gluconate Capsules and Tablets?