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Trimeprazine and Zoladex

Determining the interaction of Trimeprazine and Zoladex and the possibility of their joint administration.

Check result:

Trimeprazine <> Zoladex

Relevance: 28.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: Long-term androgen deprivation therapy can prolong the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In a single, active-controlled, clinical study comparing abarelix to LHRH (luteinizing hormone releasing hormone) agonist plus nonsteroidal antiandrogen therapy, both therapies were found to prolong the mean Fridericia-corrected QT interval (QTcF) by more than 10 msec from baseline. In approximately 20% of patients in both groups, there were either changes from baseline QTc of greater than 30 msec or end-of-treatment QTc values exceeding 450 msec. Similar results were observed in two other Phase 3 studies with abarelix and the active-control treatments. In a randomized, active-controlled trial comparing degarelix to leuprolide, three patients (

Professional:

GENERALLY AVOID: Long-term androgen deprivation therapy can prolong the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In a single, active-controlled, clinical study comparing abarelix to LHRH (luteinizing hormone releasing hormone) agonist plus nonsteroidal antiandrogen therapy, both therapies were found to prolong the mean Fridericia-corrected QT interval (QTcF) by more than 10 msec from baseline. In approximately 20% of patients in both groups, there were either changes from baseline QTc of greater than 30 msec or end-of-treatment QTc values exceeding 450 msec. Similar results were observed in two other Phase 3 studies with abarelix and the active-control treatments. In a randomized, active-controlled trial comparing degarelix to leuprolide, three patients (

References

"Product Information. Vantas (histrelin)." Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
"Product Information. Zoladex (goserelin)." Zeneca Pharmaceuticals, Wilmington, DE.
"Product Information. Eligard (leuprolide)." Sanofi Winthrop Pharmaceuticals, New York, NY.
"Product Information. Plenaxis (abarelix)." Praecis Pharmaceuticals Inc, Waltham, MA.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Trelstar (triptorelin)" Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Firmagon (degarelix)." Ferring Pharmaceuticals Inc, Tarrytown, NY.
"Product Information. Lupron (leuprolide)." TAP Pharmaceuticals Inc, Deerfield, IL.

Trimeprazine

Generic Name: trimeprazine

Brand name:

Synonyms: n.a.

What is Trimeprazine?

Zoladex

Generic Name: goserelin

Brand name: Zoladex

Synonyms: n.a.

What is Zoladex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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