Trimipramine Maleate and Xylometazoline
Determining the interaction of Trimipramine Maleate and Xylometazoline and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with tri- or tetra-cyclic antidepressants may theoretically potentiate the sympathomimetic effects (e.g., hypertension, tachycardia) of systemically absorbed xylometazoline following topical (i.e., nasal) administration. The proposed mechanism may involve additive or synergistic increases in circulating catecholamines, such as noradrenaline (norepinephrine). MANAGEMENT: Until further information is available, caution is advised if a tri- or tetra-cyclic antidepressant is used concomitantly with topical xylometazoline. Blood pressure and heart rate should be monitored at regular intervals during concomitant therapy. A dose reduction or discontinuation of concomitant therapy should be considered in patients who experience a sustained increase in blood pressure or heart rate. References Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]): Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Professional:MONITOR: Coadministration with tri- or tetra-cyclic antidepressants may theoretically potentiate the sympathomimetic effects (e.g., hypertension, tachycardia) of systemically absorbed xylometazoline following topical (i.e., nasal) administration. The proposed mechanism may involve additive or synergistic increases in circulating catecholamines, such as noradrenaline (norepinephrine).
MANAGEMENT: Until further information is available, caution is advised if a tri- or tetra-cyclic antidepressant is used concomitantly with topical xylometazoline. Blood pressure and heart rate should be monitored at regular intervals during concomitant therapy. A dose reduction or discontinuation of concomitant therapy should be considered in patients who experience a sustained increase in blood pressure or heart rate.
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: trimipramine
Brand name: Surmontil
Synonyms: Trimipramine
Generic Name: xylometazoline nasal
Brand name: Triaminic Decongestant, Otrivin
Synonyms: Xylometazoline nasal
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Trimipramine Maleate-Xylometazoline nasal
- Trimipramine Maleate-Xylon
- Trimipramine Maleate-Xyntha
- Trimipramine Maleate-Xyosted
- Trimipramine Maleate-Xyrem
- Trimipramine Maleate-Xyzal
- Xylometazoline-Trimo San Jelly
- Xylometazoline-Trimo-San vaginal
- Xylometazoline-Trimox
- Xylometazoline-Trimpex
- Xylometazoline-Trinatal GT
- Xylometazoline-TriNessa