Twinrix Junior and Vaxchora

• Generic Name: hepatitis a adult vaccine / hepatitis b adult vaccine
• Dosage Forms: n.a.
• Other Brand Names: Twinrix Preservative-Free, Twinrix

Hepatitis A and hepatitis B combination vaccine is used to prevent infection caused by the hepatitis A and hepatitis B virus. The vaccine works by causing your body to produce its own protection (antibodies) against the disease.

Hepatitis A is a serious disease of the liver that can cause death. It is caused by the hepatitis A virus (HAV), and is spread most often through infected food or water. Hepatitis A may also be spread by close person-to-person contact with infected persons (such as between persons living in the same household). Although some infected persons do not appear to be sick, they are still able to spread the virus to others.

Hepatitis A is less common in the U.S. and other areas of the world that have a higher level of sanitation and good water and sewage (waste) systems. However, it is a significant health problem in parts of the world that do not have such systems. If you are traveling to certain countries or remote (out-of-the-way) areas, hepatitis A vaccine will help protect you from hepatitis A disease.

Hepatitis B is caused by hepatitis B virus (HBV), and is spread by contact with body fluids, such as blood, saliva, semen, or vaginal fluids; by needle sticks or sharing needles; or from mother to child.

Hepatitis A and hepatitis B combination vaccine is recommended for all persons 18 years of age or older who are at risk from infection from their jobs or some behaviors, or from traveling to the following parts of the world:

• Africa.
• Central and South America.
• Eastern and Southern Europe.
• South and Southeast Asia (except Japan).
• The Caribbean.
• The Middle East.
• The former Soviet Union

Hepatitis A and Hepatitis B combination vaccine is also recommended for:

• Military personnel.
• Persons living in or moving to areas that have a high rate of HAV infection and who are at a high risk of HBV infection.
• Persons engaging in high-risk sexual activity, such as homosexual and bisexual males.
• Persons who use illegal injection drugs.
• Persons at risk through their work, such as laboratory workers who handle live hepatitis A and hepatitis B virus, police, and those who give first aid or medical help, and workers who come in contact with stool or sewage.
• People who work in child daycare centers and correctional facilities, residents of drug and alcohol treatment centers, and patients and staff in hemodialysis units.
• People who are at increased risk for HBV infection and who are in close contact with patients that have hepatitis A or B.
• Persons with hemophilia.
• Persons with chronic liver disease.

This vaccine is to be given only by or under the supervision of a doctor.

• Generic Name: cholera vaccine, live
• Dosage Forms: n.a.
• Other Brand Names: Vaxchora

Cholera is a bacterial infection that can cause severe, life-threatening diarrhea. Cholera is caused by coming into contact with water or food contaminated by feces infected with Vibrio cholerae bacteria.

Cholera is common in areas where sewage and drinking water are not adequately treated to remove contaminants. Cholera spreads easily in areas where there is poor hygiene and sanitation. Cholera outbreaks often occur in areas of overcrowding, among refugees fleeing from political or natural emergencies, or in other situations where there is limited access to safe drinking water and adequate toileting facilities.

Cholera is rare in the US and other developed countries with advanced water and sewage treatment methods. It is more common to become infected during international travel to areas where cholera often occurs, such as Africa, Southeast Asia, and Haiti.

You can also become infected by eating food contaminated as a result of handling by a person infected with cholera. Most cholera cases that occur in the US result from eating seafood that a traveler has brought from another country. Eating raw or undercooked shellfish may also be a source of cholera, especially shellfish from the Gulf of Mexico.

Most people with cholera have no symptoms, but the main symptom is sudden diarrhea, which can begin within 2 hours to 5 days after a person is infected. If diarrhea is severe, the body can quickly lose vital fluids and electrolytes, which can lead to dehydration or shock. If cholera is not treated quickly, death can occur within a matter of hours. Even without symptoms, infected people can still have cholera bacteria in their stools for up to 2 weeks.

With certain precautions, cholera can be easily treated or prevented. The Vaxchora is used to help prevent this disease in people who plan to travel to places where cholera is common.

This vaccine works by exposing you to a small dose of live cholera bacteria, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

Vaxchora is for use in adults ages 18 through 64 years old.

Like any vaccine, the Vaxchora may not provide protection from disease in every person.