Tylenol Cold & Flu Severe and Zantac (Ranitidine Syrup)
Determining the interaction of Tylenol Cold & Flu Severe and Zantac (Ranitidine Syrup) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Animal studies have suggested that ranitidine may potentiate the hepatotoxicity of acetaminophen, however, a double-blind placebo-controlled crossover study has failed to confirm this finding in humans. Acetaminophen dosage adjustments are not indicated.
- Rogers SA, Gale KC, Newton JF, et al "Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity." J Pharmacol Exp Ther 245 (1988): 887-94
- Jack D, Thomas M, Skidmore IF "Ranitidine and paracetamol metabolism." Lancet 2 (1985): 1067
Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine
Brand name: DayQuil Severe Cold & Flu, Delsym Cough Plus Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Severe Cold, Sudafed PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold Multi-Symptom Severe, Mucinex Sinus-Max, Sudafed PE Cold/Cough, Tylenol Cold Head Congestion, Tylenol Cold Multi Symptom, Tylenol Cold/Flu Severe, Vicks DayQuil Severe Cold/Flu
Synonyms: n.a.
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Zantac
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Tylenol Cold & Flu Severe-Zantac (Ranitidine Tablets and Capsules)
- Tylenol Cold & Flu Severe-Zantac Cool Mint
- Tylenol Cold & Flu Severe-Zantac Injection
- Tylenol Cold & Flu Severe-Zapzyt Cleansing Topical
- Tylenol Cold & Flu Severe-Zapzyt Topical
- Tylenol Cold & Flu Severe-Zarah
- Zantac (Ranitidine Syrup)-Tylenol Cold Head Congestion (Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine Caps & Tabs)
- Zantac (Ranitidine Syrup)-Tylenol Cold Head Congestion (Acetaminophen/Chlorpheniramine/Dextromethorphan/Phenylephrine Caps & Tabs)
- Zantac (Ranitidine Syrup)-Tylenol Cold Multi Symptom
- Zantac (Ranitidine Syrup)-Tylenol Cold Multi-Symptom (Acetaminophen, Dextromethorphan, and Phenylephrine Liquid)
- Zantac (Ranitidine Syrup)-Tylenol Cold Multi-Symptom (Acetaminophen, Doxylamine, Dextromethorphan, and Phenylephrine Liquid)
- Zantac (Ranitidine Syrup)-Tylenol Cold Multi-Symptom (Acetaminophen/Chlorpheniramine/Dextromethorphan/Phenylephrine Caps & Tabs)