Tylenol Cold Multi-Symptom Severe and Zidovudine Capsules and Tablets
Determining the interaction of Tylenol Cold Multi-Symptom Severe and Zidovudine Capsules and Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Case reports have suggested that the concomitant use of zidovudine and acetaminophen may potentiate the risk of bone marrow suppression and hepatotoxicity; however data have been conflicting. The mechanism is unknown. Until more information is available, patients taking both drugs concurrently should be monitored for the development of hepatotoxicity and bone marrow toxicity.
- Gill PS, Rarick M, Brynes RK, et al "Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med 107 (1987): 502-5
- Sattler FR, Ko R, Antoniskis D, et al "Acetaminophen does not impair clearance of zidovudine." Ann Intern Med 114 (1991): 937-40
- Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60
- Goldsmith JC, Irvine W "Reversible agranulocytosis related to azidothymidine therapy." Am J Hematol 30 (1989): 263-4
- Ameer B "Acetaminophen hepatotoxicity augmented by zidovudine." Am J Med 95 (1993): 342
- Shriner K, Goetz MB "Severe hepatoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med 93 (1992): 94-6
Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine
Brand name: DayQuil Severe Cold & Flu, Delsym Cough Plus Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Severe Cold, Sudafed PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold Multi-Symptom Severe, Mucinex Sinus-Max, Sudafed PE Cold/Cough, Tylenol Cold Head Congestion, Tylenol Cold Multi Symptom, Tylenol Cold/Flu Severe, Vicks DayQuil Severe Cold/Flu
Synonyms: n.a.
Generic Name: zidovudine
Brand name: Retrovir
Synonyms: Zidovudine (oral/injection), Zidovudine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Tylenol Cold Multi-Symptom Severe-Zidovudine Injection
- Tylenol Cold Multi-Symptom Severe-Zidovudine Intravenous
- Tylenol Cold Multi-Symptom Severe-Zidovudine Oral Solution
- Tylenol Cold Multi-Symptom Severe-Zidovudine oral/injection
- Tylenol Cold Multi-Symptom Severe-Zidovudine Syrup
- Tylenol Cold Multi-Symptom Severe-Zidovudine Tablets
- Zidovudine Capsules and Tablets-Tylenol Cold Relief
- Zidovudine Capsules and Tablets-Tylenol Cold Relief Nighttime
- Zidovudine Capsules and Tablets-Tylenol Cold Severe Congestion
- Zidovudine Capsules and Tablets-Tylenol Cough/Sore Throat (Acetaminophen and Dextromethorphan Liquid)
- Zidovudine Capsules and Tablets-Tylenol Cough/Sore Throat (Acetaminophen, Dextromethorphan, and Doxylamine Liquid)
- Zidovudine Capsules and Tablets-Tylenol Infants