Uroxatral and Zanaflex Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using tiZANidine and alfuzosin together can lower your blood pressure and affect the rhythm of your heart especially if you have a heart condition. This can cause a slow heartbeat, headaches, dizziness, and fast or irregular heartbeats. If you take both medications together, tell your doctor if you have any of these symptoms. Avoid driving until you know how the medications will affect you. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Tizanidine has alpha-adrenergic agonist activities and may potentiate the hypotensive effects of other medications, including alfuzosin. In addition, both alfuzosin and tizanidine may cause prolongation of the QTc interval. Theoretically, coadministration of agents that can prolong the QT interval may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential related to their effects on the QT interval. Tizanidine has been associated with QT interval prolongation during toxicity studies with dogs. During a clinical study involving 45 healthy male subjects, average prolongation of QTc interval at peak plasma concentrations was less with single doses of alfuzosin 10 mg than with alfuzosin 40 mg, and both were less than with moxifloxacin 400 mg. Heart rate increased by an average of 5.2 bpm with alfuzosin 10 mg, 5.8 bpm with alfuzosin 40 mg, and 2.8 bpm with moxifloxacin 400 mg. Neither drug has been associated with torsade de pointes in humans.

MANAGEMENT: Caution and clinical monitoring are recommended during concurrent therapy. Patients should be advised to notify their physician if they experience orthostatic symptoms (e.g., lightheadedness, dizziness, syncope) and to seek medical help if they experience palpitations, or irregular heartbeats.

Uroxatral

Generic Name: alfuzosin

Brand name: Uroxatral

Synonyms: n.a.

What is Uroxatral?

Zanaflex Tablets

Generic Name: tizanidine

Brand name: Zanaflex

Synonyms: Zanaflex

What is Zanaflex Tablets?