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Valbenazine Tosylate and Zyvox

Determining the interaction of Valbenazine Tosylate and Zyvox and the possibility of their joint administration.

Check result:
Valbenazine Tosylate <> Zyvox
Relevance: 14.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using valbenazine together with linezolid may increase the risk of side effects of these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration of valbenazine with monoamine oxidase inhibitors (MAOIs) may increase the risk of adverse effects such as serotonin syndrome or reduce the therapeutic effects of valbenazine. The mechanism for this interaction has not been delineated; however, concomitant use of these drugs may increase the concentration of monoamine neurotransmitters in synapses.

MANAGEMENT: The use of valbenazine with MAOIs should generally be avoided. If concomitant use is required, caution and close clinical and laboratory monitoring are recommended. Alternative treatment may be required if an interaction is suspected.

References
  • "Product Information. Ingrezza (valbenazine)." Neurocrine Biosciences, Inc., San Diego, CA.
Valbenazine Tosylate

Generic Name: valbenazine

Brand name: Ingrezza

Synonyms: Valbenazine

Zyvox

Generic Name: linezolid

Brand name: Zyvox

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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