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Valcyte and Videx EC

Determining the interaction of Valcyte and Videx EC and the possibility of their joint administration.

Check result:

Valcyte <> Videx EC

Relevance: 15.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using didanosine together with valGANciclovir may increase the effects of didanosine. Contact your doctor if you experience abdominal pain, nausea, vomiting, diarrhea, weakness, dizziness, lightheadedness, irregular heartbeat, or numbness, pain, or tingling in the hands and feet. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The coadministration of didanosine and ganciclovir may result in significantly elevated plasma concentrations of didanosine, while the pharmacokinetics of ganciclovir are minimally affected. In a study consisting of 11 subjects with HIV infection, ganciclovir (1 gram orally every 8 hours) increased the peak plasma concentration and area under the concentration-time curve of didanosine (200 mg orally every 12 hours) by an average of 58% and 71%, respectively. Other studies have reported similar or even greater alterations with both intravenous and oral ganciclovir. The mechanism is unknown but may involve competitive inhibition of didanosine renal tubular secretion or increased bioavailability of didanosine by ganciclovir. Caution is advised if didanosine must be used concomitantly with ganciclovir or its prodrug, valganciclovir.

MANAGEMENT: Close monitoring for toxicities associated with didanosine such as pancreatitis, lactic acidosis, and peripheral neuropathy is recommended during concurrent therapy. Patients should be advised to promptly notify their physician if they experience possible symptoms of toxicity (e.g., abdominal pain, nausea, vomiting, diarrhea, weakness, dizziness, lightheadedness, irregular heartbeat, or numbness, pain, or tingling in the hands and feet).

References

"Product Information. Cytovene (ganciclovir)." Genentech, South San Francisco, CA.
Taburet AM, Singlas E "Drug interactions with antiviral drugs." Clin Pharmacokinet 30 (1996): 385-401
Trapnell CB, Cimoch P, Gaines K, Jung D, Hale M, Lavelle J "Altered didanosine pharmacokinetics with concomitant oral ganciclovir." Clin Pharmacol Ther 55 (1994): 193
Jung D, Griffy K, Dorr A, Raschke R, Tarnowski TL, Hulse J, Kates RE "Effect of high-dose oral ganciclovir on didanosine disposition in human immunodeficiency virus (HIV)-positive patients." J Clin Pharmacol 38 (1998): 1057-62
"Product Information. Valcyte (valganciclovir)" Roche Laboratories, Nutley, NJ.
"Product Information. Videx (didanosine)." Bristol-Myers Squibb, Princeton, NJ.

Valcyte

Generic Name: valganciclovir

Brand name: Valcyte

Synonyms: n.a.

What is Valcyte?

Videx EC

Generic Name: didanosine

Brand name: Videx, Videx EC

Synonyms: n.a.

What is Videx EC?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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