Valdecoxib and Zovia 1/35

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ethinyl estradiol together with valdecoxib may increase the effects of ethinyl estradiol. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with valdecoxib may increase the plasma concentrations of ethinylestradiol and norethisterone. The mechanism of interaction has not been described, although valdecoxib has been shown to be a weak inhibitor of CYP450 3A4, an isoenzyme of which ethinylestradiol and norethisterone are substrates. According to product labeling, coadministration of valdecoxib (40 mg twice a day) and norethisterone-ethinylestradiol (1 mg-35 mcg oral contraceptive combination) resulted in a 20% and 34% increase, respectively, in the systemic exposure (AUC) of the hormones. The clinical significance of these changes in terms of safety is unknown. However, an increase in ethinylestradiol exposure can increase the incidence of adverse reactions associated with oral contraceptives such as venous thromboembolic complications and certain cancers.

MANAGEMENT: The potential increase in ethinylestradiol concentration should be considered when selecting an oral contraceptive for use with valdecoxib.

Valdecoxib

Generic Name: valdecoxib

Brand name:

Synonyms: Valdecoxib (Oral)

What is Valdecoxib?

Zovia 1/35

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/35E

What is Zovia 1/35?