Valproate sodium Intravenous and Varenicline tartrate

• Generic Name: valproic acid
• Dosage Forms: n.a.
• Other Brand Names: Depakene, Depacon, Stavzor, Valproate Sodium

Valproate sodium injection is used to treat certain types of seizures (epilepsy). Valproate sodium is an anticonvulsant that works in the brain tissue to stop seizures.

Valproate sodium is to be given only by or under the direct supervision of your doctor.

• Generic Name: varenicline
• Dosage Forms: n.a.
• Other Brand Names: Chantix, Chantix Starter Pack, Chantix Continuing Month

Adjunct in the cessation of cigarette smoking.

USPHS guideline for the treatment of tobacco use and dependence recommends varenicline as one of several first-line drugs that may reliably increase long-term smoking abstinence rates.

In clinical studies, varenicline therapy increased continuous abstinence rates compared with placebo or active comparator (e.g., bupropion). Also reduced urge to smoke.

In studies in patients with stable, documented cardiovascular disease and patients with mild to moderate COPD, efficacy of varenicline was comparable to that in the general smoking population without these conditions.

Also evaluated in patients with stable major depressive disorder in a postmarketing study; benefits also observed in this population without evidence of increased neuropsychiatric effects. (See Neuropsychiatric Symptoms and Suicidality under Cautions.)

Efficacy and safety of varenicline given in conjunction with other smoking cessation therapies (e.g., bupropion, nicotine replacement therapy) not established.