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Vemurafenib and Verapamil Immediate-Release Tablets

Determining the interaction of Vemurafenib and Verapamil Immediate-Release Tablets and the possibility of their joint administration.

Check result:

Vemurafenib <> Verapamil Immediate-Release Tablets

Relevance: 23.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with verapamil may increase the plasma concentrations of vemurafenib. The mechanism is inhibition of CYP450 3A4 and P-glycoprotein by verapamil. Vemurafenib has been shown in vitro to be a substrate of CYP450 3A4 and a weak substrate of P-glycoprotein. The clinical significance is unknown and clinical data are currently lacking.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."

Vemurafenib

Generic Name: vemurafenib

Brand name: Zelboraf

Synonyms: n.a.

What is Vemurafenib?

Verapamil Immediate-Release Tablets

Generic Name: verapamil

Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM

Synonyms: Verapamil

What is Verapamil Immediate-Release Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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