Vemurafenib and Vicks Formula 44 D Cough

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Vemurafenib may increase the blood levels and effects of dextromethorphan. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with vemurafenib may increase the plasma concentrations of drugs that are substrates of the CYP450 1A2 and/or 2D6 isoenzymes. The mechanism is decreased clearance due to inhibition of CYP450 1A2 and 2D6 activity by vemurafenib. The interaction has been studied with caffeine and dextromethorphan, probe substrates for CYP450 1A2 and 2D6, respectively. In an in vivo phenotypic cocktail drug-drug interaction study in patients with cancer, caffeine systemic exposure (AUC) increased by 2.6-fold when a single dose of the CYP probe substrate cocktail was administered following treatment with vemurafenib 960 mg twice daily for 15 days, while dextromethorphan AUC increased by 47%.

MANAGEMENT: Caution is advised if vemurafenib must be used concurrently with drugs that undergo metabolism by CYP450 1A2 and/or 2D6. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever vemurafenib is added to or withdrawn from therapy. Concomitant use of vemurafenib and substrates of CYP450 1A2 and/or 2D6 with a narrow therapeutic index (e.g., antiarrhythmics; theophylline) should be avoided if possible.

Vemurafenib

Generic Name: vemurafenib

Brand name: Zelboraf

Synonyms: n.a.

What is Vemurafenib?

Vicks Formula 44 D Cough

Generic Name: dextromethorphan / phenylephrine

Brand name: Albatussin Pediatric, Pedia Care Multi-Symptom Cold, PediaCare Children’s Multi-Symptom, Sudafed PE Cold & Cough Child, Triacting Day Time Cold/Cough, Vicks Formula 44D Cough & Sinus Congestion Relief, Triaminic Daytime Cough & Cold, Triaminic Thin Strips Cough and Congestion, Triaminic Toddler Cough and Cold Thin Strips, Triaminic Day Time Cold & Cough, Dimetapp Cold & Cough, Triaminic Thin Strips Infant Decongestant Plus Cough, PediaCare Infant Decongestant & Cough, Sudafed PE Children's Cold & Cough

Synonyms: n.a.

What is Vicks Formula 44 D Cough?