Verapamil Extended Release Tablets and Viramune (Nevirapine Tablets)
Determining the interaction of Verapamil Extended Release Tablets and Viramune (Nevirapine Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with nevirapine may decrease the plasma concentrations and therapeutic efficacy of drugs that are substrates of CYP450 3A4. The proposed mechanism is increased clearance due to nevirapine-mediated induction of CYP450 3A4. MANAGEMENT: Caution is advised if nevirapine is used concomitantly with drugs that are CYP450 3A4 substrates. Dosage adjustments as well as clinical and laboratory monitoring of coadministered drugs should be considered whenever nevirapine is added to or withdrawn from therapy. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Viramune XR (nevirapine)." Boehringer Ingelheim, Ridgefield, CT. Cerner Multum, Inc. "Australian Product Information." O 0 "Product Information. Viramune (nevirapine)." Boehringer-Ingelheim, Ridgefield, CT. View all 4 references
Professional:MONITOR: Coadministration with nevirapine may decrease the plasma concentrations and therapeutic efficacy of drugs that are substrates of CYP450 3A4. The proposed mechanism is increased clearance due to nevirapine-mediated induction of CYP450 3A4.
MANAGEMENT: Caution is advised if nevirapine is used concomitantly with drugs that are CYP450 3A4 substrates. Dosage adjustments as well as clinical and laboratory monitoring of coadministered drugs should be considered whenever nevirapine is added to or withdrawn from therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Viramune XR (nevirapine)." Boehringer Ingelheim, Ridgefield, CT.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Viramune (nevirapine)." Boehringer-Ingelheim, Ridgefield, CT.
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
Generic Name: nevirapine
Brand name: Viramune, Viramune XR
Synonyms: Viramune
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Verapamil Extended Release Tablets-Viramune O/S
- Verapamil Extended Release Tablets-Viramune Suspension
- Verapamil Extended Release Tablets-Viramune XR
- Verapamil Extended Release Tablets-Virasal
- Verapamil Extended Release Tablets-Virasal Topical
- Verapamil Extended Release Tablets-Viravan P
- Viramune (Nevirapine Tablets)-Verapamil Hydrochloride
- Viramune (Nevirapine Tablets)-Verapamil Hydrochloride PM
- Viramune (Nevirapine Tablets)-Verapamil Immediate-Release Tablets
- Viramune (Nevirapine Tablets)-Verapamil Injection
- Viramune (Nevirapine Tablets)-Verapamil Intravenous
- Viramune (Nevirapine Tablets)-Verapamil Long-Acting Capsules