Verapamil Immediate-Release Tablets and Vincristine
Determining the interaction of Verapamil Immediate-Release Tablets and Vincristine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:In vitro tests have shown that verapamil displaces vincristine from protein-binding sites--particularly alpha(1) -acid glycoprotein, or AGP. The clinical significance is unknown. If verapamil and vincristine are used concomitantly, close neurological observation is advised.
- Abdel-Rahman M, Wosch F, Harder S, Woodcock BG "Interaction between verapamil and vincristine binding to plasma proteins." Int J Clin Pharmacol Ther Toxicol 30 (1992): 536-7
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
Generic Name: vincristine
Brand name: Oncovin, Vincasar PFS
Synonyms: VinCRIStine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Verapamil Immediate-Release Tablets-Vincristine (Liposomal)
- Verapamil Immediate-Release Tablets-Vincristine Intravenous
- Verapamil Immediate-Release Tablets-Vincristine liposome
- Verapamil Immediate-Release Tablets-Vincristine liposome Intravenous
- Verapamil Immediate-Release Tablets-Vincristine Sulfate
- Verapamil Immediate-Release Tablets-Vinorelbine
- Vincristine-Verapamil Injection
- Vincristine-Verapamil Intravenous
- Vincristine-Verapamil Long-Acting Capsules
- Vincristine-Verapamil Long-Acting Tablets
- Vincristine-Verapamil oral/injection
- Vincristine-Verapamil Sustained-Release Capsules