Verapamil Immediate-Release Tablets and Zelboraf
Determining the interaction of Verapamil Immediate-Release Tablets and Zelboraf and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with verapamil may increase the plasma concentrations of vemurafenib. The mechanism is inhibition of CYP450 3A4 and P-glycoprotein by verapamil. Vemurafenib has been shown in vitro to be a substrate of CYP450 3A4 and a weak substrate of P-glycoprotein. The clinical significance is unknown and clinical data are currently lacking.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Verapamil Immediate-Release Tablets-Zelnorm
- Verapamil Immediate-Release Tablets-Zema-Pak
- Verapamil Immediate-Release Tablets-Zembrace SymTouch
- Verapamil Immediate-Release Tablets-Zembrace SymTouch injection
- Verapamil Immediate-Release Tablets-Zemdri
- Verapamil Immediate-Release Tablets-Zemplar
- Zelboraf-Verapamil Injection
- Zelboraf-Verapamil Intravenous
- Zelboraf-Verapamil Long-Acting Capsules
- Zelboraf-Verapamil Long-Acting Tablets
- Zelboraf-Verapamil oral/injection
- Zelboraf-Verapamil Sustained-Release Capsules