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Versed and Zelboraf

Determining the interaction of Versed and Zelboraf and the possibility of their joint administration.

Check result:

Versed <> Zelboraf

Relevance: 06.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Vemurafenib may decrease the plasma concentration of midazolam. The mechanism is related to induction of hepatic CYP450 3A4 enzymes responsible for the metabolism of midazolam. Administration of a single dose of midazolam after repeat dosing with vemurafenib for 15 days, resulted in a mean 39% decrease (maximum 80%) in midazolam plasma exposure. The clinical significance is unknown, but may depend on the dosage and duration of vemurafenib therapy.

References

"Product Information. Zelboraf (vemurafenib)." Genentech, South San Francisco, CA.
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Versed

Generic Name: midazolam

Brand name: Versed, Nayzilam

Synonyms: n.a.

What is Versed?

Zelboraf

Generic Name: vemurafenib

Brand name: Zelboraf

Synonyms: n.a.

What is Zelboraf?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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