Victrelis and Xanax

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Boceprevir may increase the blood levels and effects of ALPRAZolam. This can increase the risk of side effects including excessive drowsiness and breathing difficulties. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with the hepatitis C virus (HCV) NS3/4A protease inhibitors, boceprevir and telaprevir, may increase the plasma concentrations of alprazolam. The mechanism involves inhibition of CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of alprazolam. In 17 study subjects, administration of a single 0.5 mg dose of alprazolam during treatment with telaprevir 750 mg every 8 hours for 10 days increased the alprazolam systemic exposure (AUC) by an average of 35% compared to administration alone. Alprazolam peak plasma concentration (Cmax) did not change significantly. No data are available for boceprevir; however, a similar interaction is expected.

MANAGEMENT: Caution is advised if alprazolam is used in combination with boceprevir or telaprevir. The potential for increased pharmacologic effects of alprazolam, including central nervous system and respiratory depression, should be considered. The interaction is not expected to occur with lorazepam, oxazepam or temazepam, which are primarily metabolized via glucuronidation.

Victrelis

Generic Name: boceprevir

Brand name: Victrelis

Synonyms: n.a.

What is Victrelis?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?