Drug search by name

Vinblastine and Vincristine

Determining the interaction of Vinblastine and Vincristine and the possibility of their joint administration.

Check result:

Vinblastine <> Vincristine

Relevance: 15.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

An in vitro test has shown vincristine to have inhibitory effects on the biotransformation of vinblastine. Similarly, it is likely that vinblastine would inhibit the biotransformation of vincristine. Both drugs are believed to be metabolized by the liver cytochrome P-450. These drugs may also have many overlapping side effects. The clinical significance of this interaction has not been established. If vincristine and vinblastine are used concomitantly, caution and close observation are advised.

References

Zhou-Pan XR, Seree E, Zhou XJ, et al "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res 53 (1993): 5121-6

Vinblastine

Generic Name: vinblastine

Brand name: Velban

Synonyms: VinBLAStine

What is Vinblastine?

Vincristine

Generic Name: vincristine

Brand name: Oncovin, Vincasar PFS

Synonyms: VinCRIStine

What is Vincristine?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions