Vismodegib and Zegerid (Omeprazole and Sodium Bicarbonate Powder Packets)
Determining the interaction of Vismodegib and Zegerid (Omeprazole and Sodium Bicarbonate Powder Packets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The solubility of vismodegib is known to be pH-dependent (0.1 mcg/mL at pH 7 and 0.99 mg/mL at pH 1) and drugs that alter the pH of the upper gastrointestinal tract may affects its solubility and reduce its bioavailability. However, a clinically significant pharmacokinetic effect has not been observed, with results from a clinical study showing a 33% reduction in the unbound drug concentrations of vismodegib after 7 days of concomitant therapy with the proton pump inhibitor rabeprazole (20 mg, given 2 hours before each vismodegib administration).
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Erivedge (vismodegib)." Genentech, South San Francisco, CA.
Generic Name: omeprazole / sodium bicarbonate
Brand name: Zegerid, Zegerid OTC
Synonyms: Zegerid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Vismodegib-Zegerid OTC
- Vismodegib-Zejula
- Vismodegib-Zelapar
- Vismodegib-Zelapar Oral
- Vismodegib-Zelboraf
- Vismodegib-Zelnorm
- Zegerid (Omeprazole and Sodium Bicarbonate Powder Packets)-VisRx Dose Pack
- Zegerid (Omeprazole and Sodium Bicarbonate Powder Packets)-Vistacot
- Zegerid (Omeprazole and Sodium Bicarbonate Powder Packets)-Vistaril
- Zegerid (Omeprazole and Sodium Bicarbonate Powder Packets)-Vistaril IM
- Zegerid (Omeprazole and Sodium Bicarbonate Powder Packets)-Vistaril Injection
- Zegerid (Omeprazole and Sodium Bicarbonate Powder Packets)-Vistide