Vitamin B6, Ginger, Folic Acid, and Calcium and Xalkori

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ginger may increase the blood levels and side effects of crizotinib. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience fever, rash, abdominal pain, yellowing of the skin or the whites of your eyes, dark urine, fatigue, weakness, unusual bleeding or bruising, loss of appetite, nausea, or vomiting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Limited data suggests that coadministration with ginger may increase the plasma concentrations and the risk of toxicity of crizotinib. The proposed mechanism, based on in vitro data, may be attributed to decreased clearance due to ginger-mediated inhibition of CYP450 3A4 and/or P-glycoprotein (P-gp). Ginger has previously been shown to inhibit CYP450 3A4, 2C9, and P-gp activities in vitro. In one case report, increased plasma levels and hepatotoxicity developed in a 48-year old woman receiving crizotinib (250 mg twice daily) following consumption of a drink containing grated ginger. Previously, the patient had tolerated crizotinib well. The concentration of crizotinib, two days after its discontinuation, was 1.8-fold higher than the previous level measured prior to the initiation of ginger.

MANAGEMENT: Until more information is available, caution is advised when ginger is used concomitantly with crizotinib. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for crizotinib whenever ginger is added to or withdrawn from therapy.

Vitamin B6, Ginger, Folic Acid, and Calcium

Generic Name: calcium / folic acid / ginger / pyridoxine

Brand name: Prenaissance Next, Prenaissance Next-B

Synonyms: n.a.

What is Vitamin B6, Ginger, Folic Acid, and Calcium?

Xalkori

Generic Name: crizotinib

Brand name: Xalkori

Synonyms: n.a.

What is Xalkori?