Vitekta and Zinc Gluconate Capsules and Tablets
Determining the interaction of Vitekta and Zinc Gluconate Capsules and Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.ADJUST DOSING INTERVAL: Coadministration with supplements containing polyvalent cations such as zinc may decrease the plasma concentrations of integrase strand transfer inhibitors (INSTIs) such as elvitegravir and raltegravir. The mechanism involves chelation of the INSTI by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. The clinical relevance is unknown. MANAGEMENT: If concomitant use is required, monitor for virologic efficacy and administer the INSTI such as elvitegravir or raltegravir at least 2 hours before or 6 hours after supplements containing polyvalent cations such as zinc. References US National Library of Medicine "Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Available from: URL: https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/287/insti-drug-interactions." ([2019, Nov 6]):
Professional:ADJUST DOSING INTERVAL: Coadministration with supplements containing polyvalent cations such as zinc may decrease the plasma concentrations of integrase strand transfer inhibitors (INSTIs) such as elvitegravir and raltegravir. The mechanism involves chelation of the INSTI by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. The clinical relevance is unknown.
MANAGEMENT: If concomitant use is required, monitor for virologic efficacy and administer the INSTI such as elvitegravir or raltegravir at least 2 hours before or 6 hours after supplements containing polyvalent cations such as zinc.
- US National Library of Medicine "Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Available from: URL: https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/287/insti-drug-interactions." ([2019, Nov 6]):
Generic Name: zinc gluconate
Brand name: Orazinc, Orazinc 110
Synonyms: Zinc gluconate, Zinc Gluconate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Vitekta-Zinc Gluconate Extended-Release Tablets
- Vitekta-Zinc Gluconate Lozenges
- Vitekta-Zinc sulfate
- Vitekta-Zinc Sulfate Capsules and Tablets
- Vitekta-Zinc Sulfate Extended-Release Tablets
- Vitekta-Zinc Sulfate Injection
- Zinc Gluconate Capsules and Tablets-Vitetal Elixir
- Zinc Gluconate Capsules and Tablets-Vitonic
- Zinc Gluconate Capsules and Tablets-Vitrakvi
- Zinc Gluconate Capsules and Tablets-Vitrakvi (Larotrectinib Capsules)
- Zinc Gluconate Capsules and Tablets-Vitrakvi (Larotrectinib Oral Solution)
- Zinc Gluconate Capsules and Tablets-Vitrase