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Warfarin and Zebutal

Determining the interaction of Warfarin and Zebutal and the possibility of their joint administration.

Check result:

Warfarin <> Zebutal

Relevance: 13.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Butalbital can reduce the blood levels of warfarin, which may make the medication less effective in preventing blood clots. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment and more frequent monitoring of your prothrombin time or International Normalized Ratio (INR) to safely use both medications. You should seek immediate medical attention if you notice any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, and/or pain, redness or swelling in an extremity. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Barbiturates reduce the effects of oral anticoagulants by inducing their hepatic metabolism. Anticoagulant dosage requirements may be increased by 30% to 60%. After the barbiturate is discontinued, excessive anticoagulation and bleeding may occur if the anticoagulant dose is not reduced.

MANAGEMENT: Close attention should be paid to alterations in coagulation if a patient must take both drugs and for several weeks after the dose of the barbiturate is changed or discontinued. Alternatively, a benzodiazepine might be used instead of a barbiturate, if appropriate. Patients should be advised to promptly report any signs of blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).

References

Blouin R, Chaudhary I, Nishihara K, Cox S "The effects of liver and renal disease on stereoselective serum binding of flurbiprofen." Br J Clin Pharmacol 35 (1993): 62-4
Scaroni C, Mazzoni PL, D'Amico E, Benvenuti C, Hind ID "Pharmacokinetics of oral and rectal flurbiprofen in children." Eur J Clin Pharmacol 27 (1984): 367-9
Antlitz AM, Tolentino M, Kosai MF "Effect of butabarbital on orally administered anticoagulants." Curr Ther Res Clin Exp 10 (1968): 70-3
Goss JE, Dickhaus DW "Increased bishydroxycoumarin requirements in patients receiving phenobarbital." N Engl J Med 273 (1965): 1094-5
Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83
O'Reilly RA, Trager WF, Motley CH, Howald W "Interaction of secobarbital with warfarin pseudoracemates." Clin Pharmacol Ther 28 (1980): 187-95
Robinson DS, MacDonald MG "The effect of phenobarbital administration on the control of coagulation achieved during warfarin therapy in man." J Pharmacol Exp Ther 153 (1966): 250-3
MacDonald MG, Robinson DS "Clinical observations of possible barbiturate interference with anticoagulation." JAMA 204 (1968): 97-100
Aggeler PM, O'Reilly RA "Effect of heptabarbital on the response to bishydroxycoumarin in man." J Lab Clin Med 74 (1969): 229-38
Cucinell SA, Conney AH, Sansur M, Burns JJ "Drug interactions in man. I: lowering effect of phenobarbital on plasma levels of bishydroxycoumarin (dicumarol) and diphenylhydantoin (dilantin)." Clin Pharmacol Ther 6 (1965): 420-9
Ku LL, Ward CO, Durgin SJ "A clinical study of drug interaction and anticoagulant therapy." Drug Intell Clin Pharm 4 (1970): 300-6
Elin RJ, Ruddel M, Korn WR, Thompson BC "Discrepant results for determination of theophylline in serum from a patient with renal failure ." Clin Chem 29 (1983): 1870

Warfarin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Warfarin?

Zebutal

Generic Name: acetaminophen / butalbital / caffeine

Brand name: Capacet, Esgic, Fioricet, Margesic, Medigesic, Orbivan, Repan, Vanatol LQ, Zebutal, Esgic-Plus, Arcet, Isocet, Pharmagesic, Anoquan, Two-Dyne, Tenake, Anolor 300, Femcet, Geone, Tencet, Triad, Fiorpap, Dolmar, Endolor, Ezol, Ide-cet, G-1, Minotal, Mygracet, Pacaps, Alagesic, Americet, Nonbac, Dolgic LQ, Dolgic Plus, Vanatol S, Alagesic LQ

Synonyms: n.a.

What is Zebutal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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