Xalkori and Xanax

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Crizotinib may increase the blood levels and effects of ALPRAZolam. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with crizotinib may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by crizotinib. The interaction has been studied with midazolam, a probe substrate for CYP450 3A4. In study patients, administration of oral midazolam during treatment with crizotinib (250 mg twice daily for 28 days) resulted in a 3.7-fold increase in mean midazolam systemic exposure (AUC) compared to administration of midazolam alone, suggesting that crizotinib is a moderate inhibitor of CYP450 3A4.

MANAGEMENT: Caution is advised when crizotinib is used concomitantly with drugs that undergo metabolism by CYP450 3A4. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever crizotinib is added to or withdrawn from therapy. Concomitant use of crizotinib and substrates of CYP450 3A4 with a narrow therapeutic index (e.g., antiarrhythmic agents, benzodiazepines, ergot derivatives, immunosuppressants, vinca alkaloids) should be avoided if possible.

Xalkori

Generic Name: crizotinib

Brand name: Xalkori

Synonyms: n.a.

What is Xalkori?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?