Actoplus Met and Guanfacine Extended-Release Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

GuanFACINE may increase the blood levels and effects of metFORMIN. You may need a dose adjustment if you have been receiving metFORMIN and are starting treatment with guanFACINE. Likewise, if you have been receiving both medications, the dose of metFORMIN may need to be adjusted if guanFACINE is discontinued. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell you doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with guanfacine may theoretically increase the plasma concentrations and risk of adverse effects of drugs that are substrates of the hepatic uptake transporter, organic cation transporter 1 (OCT1). The proposed mechanism is decreased clearance due to guanfacine-mediated inhibition of OCT1. Based on in vitro data, guanfacine may be an inhibitor of OCT1 at maximal portal vein concentrations. Concomitant use of guanfacine with OCT1 substrates with a similar time to maximum concentration (Tmax) (e.g., metformin), may increase the maximum plasma concentration (Cmax) of these medicines. The clinical significance of this interaction is unknown.

MANAGEMENT: Caution is advised if guanfacine is used concomitantly with drugs that are substrates of OCT1, such as metformin. Dosage adjustment and monitoring may be required whenever guanfacine is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.

Actoplus Met

Generic Name: metformin / pioglitazone

Brand name: Actoplus Met, Actoplus Met XR

Synonyms: n.a.

What is Actoplus Met?

Guanfacine Extended-Release Tablets

Generic Name: guanfacine

Brand name: Intuniv, Tenex

Synonyms: Guanfacine, GuanFACINE

What is Guanfacine Extended-Release Tablets?