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Amphotericin b liposome Intravenous and Plazomicin Intravenous

Determining the interaction of Amphotericin b liposome Intravenous and Plazomicin Intravenous and the possibility of their joint administration.

Check result:
Amphotericin b liposome Intravenous <> Plazomicin Intravenous
Relevance: 06.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Plazomicin can sometimes cause kidney damage, and using it with amphotericin B liposomal may increase that risk. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Signs and symptoms of kidney damage may include nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Let your doctor know if you experience some or all of these problems during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The potential nephrotoxicity associated with amphotericin B and aminoglycosides may be additive.

MANAGEMENT: Just before the start and just before the end of each amphotericin infusion, hydration of the patient with 500 mL of normal saline may be helpful. The patient's renal function should be monitored frequently during therapy.

References
  • Churchill DN, Seely J "Nephrotoxicity associated with combined gentamicin - amphotericin B therapy." Nephron 19 (1977): 176-81
  • "Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.
  • "Product Information. Abelcet (amphotericin B)." Liposome Company Inc, The, Princeton, NJ.
Amphotericin b liposome Intravenous

Generic Name: amphotericin b liposomal

Brand name: Ambisome

Synonyms: Amphotericin B liposomal, Amphotericin B (Liposomal)

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.