Antabuse and Parafon Forte DSC

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using chlorzoxazone together with disulfiram may increase the effects of chlorzoxazone. Contact your doctor if you experience nausea, vomiting, diarrhea, drowsiness, dizziness, headache, muscle weakness, shallow breathing, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Disulfiram may increase the depressant effects that chlorzoxazone has on the central nervous system. The mechanism is inhibition of the CYP450 2E1 hepatic metabolism of chlorzoxazone, resulting in increased serum levels and half-life.

MANAGEMENT: Patients should be monitored for excessive CNS depressant effects. If these effects increase during concomitant administration, the clinician should consider decreasing chlorzoxazone dosage. Patients should be advised to report excessive sedation, headache or nausea to their physician.

Antabuse

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Antabuse?

Parafon Forte DSC

Generic Name: chlorzoxazone

Brand name: Lorzone, Parafon Forte DSC, Paraflex, Remular-S, Relaxazone, Eze DS, Remular, Strifon Fort

Synonyms: n.a.

What is Parafon Forte DSC?