Azathioprine Intravenous and Rheumatrex Dose Pack
Determining the interaction of Azathioprine Intravenous and Rheumatrex Dose Pack and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Methotrexate inhibits the hepatic metabolism of the thiopurines. Decreased first-pass metabolism and increased bioavailability result. The clinical significance of this interaction has not been determined and is probably insignificant with standard intermittent oral doses of methotrexate. Generally the combination has beneficial effects when used in the treatment of acute lymphoblastic leukemia.
- Balis FM, Holcenberg JS, Zimm S, et al "The effect of methotrexate on the bioavailability of oral 6-mercaptopurine." Clin Pharmacol Ther 41 (1987): 384-7
Generic Name: azathioprine
Brand name: Azasan, Imuran
Synonyms: Azathioprine, AzaTHIOprine
Generic Name: methotrexate
Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free
Synonyms: Rheumatrex
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Azathioprine Intravenous-Rheumatrex Dose Pack Oral
- Azathioprine Intravenous-Rhinall
- Azathioprine Intravenous-Rhinocort
- Azathioprine Intravenous-Rhinocort Allergy
- Azathioprine Intravenous-Rhinocort Aqua
- Azathioprine Intravenous-Rhinocort Aqua eent
- Rheumatrex Dose Pack-Azathioprine Oral, Intravenous
- Rheumatrex Dose Pack-Azathioprine Sodium
- Rheumatrex Dose Pack-Azathioprine Tablets
- Rheumatrex Dose Pack-Azedra
- Rheumatrex Dose Pack-Azedra Dosimetric
- Rheumatrex Dose Pack-Azedra Injection