Cafergot Tablets and Clozapine Oral Suspension
Determining the interaction of Cafergot Tablets and Clozapine Oral Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Caffeine may increase clozapine serum concentrations and exacerbate psychotic symptoms. The mechanism is unknown but may be related to competition for the same metabolic pathway. No specific intervention is necessary; however, if an interaction is suspected it is recommended that caffeine intake be avoided.
- Hagg S, Spiset O, Mjorndal T, Dalqvist R "Effect of caffeine on clozapine pharmacokinetics in healthy volunteers." Br J Clin Pharmacol 49 (2000): 59-63
- Odom-White A, de Leon J "Clozapine levels and caffeine." J Clin Psychiatry 57 (1996): 175-6
- Vainer JL, Chouinard G "Interaction between caffeine and clozapine." J Clin Psychopharmacol 14 (1994): 284
- Carrillo JA, Jerling M, Bertilsson L "Interaction between caffeine and clozapine - comment." J Clin Psychopharmacol 15 (1995): 376-7
Generic Name: caffeine / ergotamine
Brand name: Cafergot, Migergot, Wigraine, Cafetrate, Ercaf, Cafatine
Synonyms: Cafergot (Suppositories), Cafergot
Generic Name: clozapine
Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex
Synonyms: Clozapine, CloZAPine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cafergot Tablets-Clozapine Orally Disintegrating Tablet
- Cafergot Tablets-Clozapine Orally Disintegrating Tablets
- Cafergot Tablets-Clozapine Tablets
- Cafergot Tablets-Clozaril
- Cafergot Tablets-CNJ-016 Injection
- Cafergot Tablets-Co-Gesic
- Clozapine Oral Suspension-Caffeine
- Clozapine Oral Suspension-Caffeine and ergotamine oral/rectal
- Clozapine Oral Suspension-Caffeine and sodium benzoate Injection
- Clozapine Oral Suspension-Caffeine Capsules and Tablets
- Clozapine Oral Suspension-Caffeine Citrate
- Clozapine Oral Suspension-Caffeine Citrate Injection Solution