Cimetidine Hydrochloride and Flagyl 375
Determining the interaction of Cimetidine Hydrochloride and Flagyl 375 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with cimetidine may increase the serum concentrations of nitroimidazoles. The interaction has been reported with metronidazole. In six healthy volunteers, the half-life of a single 400 mg intravenous dose of metronidazole increased from 6.2 to 7.9 hours following six days of cimetidine administration. The plasma clearance was reduced 30%. The proposed mechanism is cimetidine inhibition of the hepatic metabolism of metronidazole. No data are available for tinidazole. This interaction is unlikely to be of clinical significance.
- "Product Information. Tindamax (tinidazole)." Presutti Laboratories Inc, Arlington Heights, IL.
- Gugler R, Jensen JC "Interaction between cimetidine and metronidazole." N Engl J Med 309 (1983): 1518-9
- Loft S, Dossing M, Sonne J, Dalhof K, Bjerrum K, Poulsen HE "Lack of effect of cimetidine on the pharmacokinetics and metabolism of a single oral dose of metronidazole." Eur J Clin Pharmacol 35 (1988): 65-8
- Loft S, Sonne J, Poulsen HE, Peterson KT, Jorgensen BG, Dossing M "Inhibition and induction of metronidazole and antipyrine metabolism." Eur J Clin Pharmacol 32 (1987): 35-41
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
Generic Name: metronidazole
Brand name: FIRST Metronidazole, Flagyl, Flagyl 375, MetroGel
Synonyms: Flagyl 375 Capsules
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cimetidine Hydrochloride-Flagyl 375 Capsules
- Cimetidine Hydrochloride-Flagyl ER
- Cimetidine Hydrochloride-Flagyl I.V. Intravenous
- Cimetidine Hydrochloride-Flagyl I.V. RTU Intravenous
- Cimetidine Hydrochloride-Flagyl Injection
- Cimetidine Hydrochloride-Flagyl Oral, Intravenous
- Flagyl 375-Cimetidine Injection
- Flagyl 375-Cimetidine Oral Solution
- Flagyl 375-Cimetidine Sodium Chloride
- Flagyl 375-Cimetidine Tablets
- Flagyl 375-Cimzia
- Flagyl 375-Cimzia (Certolizumab Prefilled Syringes)