Cimetidine Oral Solution and Tocainide
Determining the interaction of Cimetidine Oral Solution and Tocainide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Cimetidine decreases the bioavailability of tocainide in healthy subjects. The mechanism and clinical significance are unknown. Management consists of monitoring the patient's response to tocainide and consideration of checking plasma tocainide concentrations after 3 days of coadministration. Famotidine, nizatidine, and ranitidine are not expected to interact and may be considered as alternatives.
- North DS, Mattern AL, Kapil RP, Lalonde RL "The effect of histamine-2 receptor antagonists on tocainide pharmacokinetics." J Clin Pharmacol 28 (1988): 640-3
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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