Clonidine and Chlorthalidone and Lidocaine injection
Determining the interaction of Clonidine and Chlorthalidone and Lidocaine injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Clonidine prolongs the duration of lidocaine anesthesia in peripheral and central neuraxial blocks. Data have been conflicting as to whether the mechanism is pharmacokinetic or pharmacodynamic.
- Kopacz DJ, Bernards CM "Effect of Clonidine on Lidocaine Clearance In Vivo: A Microdialysis Study in Humans." Anesthesiology 95 (2001): 1371-1376
- Inomata S, Tanaka E, Miyabe M, et al. "Plasma Lidocaine Concentrations During Continuous Thoracic Epidural Anesthesia After Clonidine Premedication in Children." Anesth Analg 93 (2001): 1147-1151
Generic Name: chlorthalidone / clonidine
Brand name: Clorpres
Synonyms: n.a.
Generic Name: lidocaine
Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine
Synonyms: Lidocaine (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clonidine and Chlorthalidone-Lidocaine Injection Solution (Anesthetic)
- Clonidine and Chlorthalidone-Lidocaine Intradermal
- Clonidine and Chlorthalidone-Lidocaine Intradermal Injection
- Clonidine and Chlorthalidone-Lidocaine IV Solution
- Clonidine and Chlorthalidone-Lidocaine Jelly
- Clonidine and Chlorthalidone-Lidocaine Laryngotracheal Solution
- Lidocaine injection-Clonidine Epidural
- Lidocaine injection-Clonidine Epidural Injection
- Lidocaine injection-Clonidine Extended-Release Tablets
- Lidocaine injection-Clonidine injection
- Lidocaine injection-Clonidine Oral, Transdermal
- Lidocaine injection-Clonidine Patch