Clozapine Orally Disintegrating Tablet and Rifadin IV Intravenous
Determining the interaction of Clozapine Orally Disintegrating Tablet and Rifadin IV Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using rifAMPin together with cloZAPine may decrease the effects of cloZAPine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Rifabutin or rifampin may decrease clozapine serum concentrations by increasing the hepatic CYP450 metabolism of clozapine.
MANAGEMENT: If rifabutin or rifampin are added to or deleted from the drug therapy of a patient receiving clozapine, then clozapine serum levels and the patient's clinical response should be noted. If needed, clozapine levels may be adjusted or a different antibiotic may be selected.
- Joos AA, Frank UG, Kaschka WP "Pharmacokinetic interaction of clozapine and rifampicin in a forensic patieint with an atypical mycobacterial infection." J Clin Psychopharmacol 18 (1998): 83-5
Generic Name: clozapine
Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex
Synonyms: CloZAPine, Clozapine
Generic Name: rifampin
Brand name: Rifadin IV, Rifadin, Rimactane
Synonyms: Rifadin IV (Intravenous), Rifadin IV
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clozapine Orally Disintegrating Tablet-Rifamate
- Clozapine Orally Disintegrating Tablet-Rifampin
- Clozapine Orally Disintegrating Tablet-Rifampin and Isoniazid
- Clozapine Orally Disintegrating Tablet-Rifampin Capsules
- Clozapine Orally Disintegrating Tablet-Rifampin Injection
- Clozapine Orally Disintegrating Tablet-Rifampin Intravenous
- Rifadin IV Intravenous-Clozapine Orally Disintegrating Tablets
- Rifadin IV Intravenous-Clozapine Tablets
- Rifadin IV Intravenous-Clozaril
- Rifadin IV Intravenous-CNJ-016 Injection
- Rifadin IV Intravenous-Co-Gesic
- Rifadin IV Intravenous-Co-trimoxazole