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Dabigatran and Neut

Determining the interaction of Dabigatran and Neut and the possibility of their joint administration.

Check result:

Dabigatran <> Neut

Relevance: 22.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Taking the dabigatran and sodium bicarbonate doses too close together may interfere with the absorption of dabigatran and reduce its effectiveness. To prevent or minimize the interaction, you should take dabigatran at least two hours before sodium bicarbonate. In addition, you should avoid taking sodium bicarbonate within 24 hours after orthopedic surgery. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Coadministration with an antacid may reduce the bioavailability of dabigatran following oral administration of dabigatran etexilate. The mechanism of interaction has not been described. In population pharmacokinetic analyses, a reduction in dabigatran exposure by 35% was seen over the first 24 hours following surgery. Thereafter, a reduction of about 11% was observed.

MANAGEMENT: Dabigatran should be administered at least two hours before taking an antacid. Coadministration with dabigatran should be avoided within 24 hours after orthopedic surgery.

References

"Product Information. Pradax (dabigatran)." Boehringer Ingelheim (Canada) Ltd, Burlington, IA.

Dabigatran

Generic Name: dabigatran

Brand name: Pradaxa

Synonyms: Dabigatran Etexilate

What is Dabigatran?

Neut

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Neut Injection

What is Neut?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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