Dexamethasone and Eliglustat Tartrate
Determining the interaction of Dexamethasone and Eliglustat Tartrate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexamethasone may reduce the blood levels of eliglustat. In some cases, this may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 and/or P-glycoprotein (P-gp) may decrease the plasma concentrations of eliglustat, which is primarily metabolized by CYP450 2D6 and, to a lesser extent, CYP450 3A4. Eliglustat is also a substrate of P-gp efflux transporter. In pharmacokinetic studies, treatment with the potent CYP450 3A4/P-gp inducer rifampin (600 mg once daily) decreased eliglustat peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 90% in CYP450 2D6 extensive and intermediate metabolizers administered eliglustat 127 mg twice daily, and 95% in poor metabolizers administered eliglustat 84 mg twice daily. No data are available for use with other, less potent inducers.
MANAGEMENT: Patients receiving eliglustat with CYP450 3A4 inducers should be monitored for potentially diminished pharmacologic response to eliglustat. Concomitant use should be avoided if an interaction is suspected.
- "Product Information. Cerdelga (eliglustat)." Genzyme Corporation, Cambridge, MA.
Generic Name: dexamethasone
Brand name: Baycadron, Decadron, Dexamethasone Intensol, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA
Synonyms: Dexamethasone (Systemic)
Generic Name: eliglustat
Brand name: Cerdelga
Synonyms: Eliglustat
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dexamethasone-Elinest
- Dexamethasone-Eliphos
- Dexamethasone-Eliquis
- Dexamethasone-Eliquis Starter Pack
- Dexamethasone-Elitek
- Dexamethasone-Elixophyllin
- Eliglustat Tartrate-Dexamethasone (Systemic)
- Eliglustat Tartrate-Dexamethasone and tobramycin ophthalmic
- Eliglustat Tartrate-Dexamethasone Elixir
- Eliglustat Tartrate-Dexamethasone Elixir and Solution
- Eliglustat Tartrate-Dexamethasone Eye Drops (Suspension)
- Eliglustat Tartrate-Dexamethasone Eye Implant and Insert