Digoxin Injection and Prednisolone Sodium Phosphate Oral Solution
Determining the interaction of Digoxin Injection and Prednisolone Sodium Phosphate Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using prednisoLONE, tell your doctor if you also use digoxin. You may need a dose adjustment or special tests in order to safely take both medications together. This combination may cause increased blood pressure, irregular heartbeats, light "halos" around objects, green or yellow vision, fatigue, swollen hands, feet, or ankles (fluid retention). If you take both medications together, tell your doctor if you have any of these symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Systemically administered corticosteroids may induce hypokalemia and possibly increase the risk of digoxin toxicity. In addition, corticosteroid-induced sodium and water retention can result in edema leading to heart failure. These effects may be more common with the natural corticosteroids (cortisone, hydrocortisone) which have greater mineralocorticoid activity.
MANAGEMENT: Electrolyte levels should be monitored carefully in patients who must receive concomitant therapy.
- Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
- "Product Information. Hydeltrasol (prednisolone)." Merck & Co, Inc, West Point, PA.
Generic Name: digoxin
Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin
Synonyms: Digoxin
Generic Name: prednisolone
Brand name: Flo-Pred, Millipred, Millipred DP, Orapred, Orapred ODT, Pediapred, Veripred 20, Prelone, Hydeltra-TBA, Hydeltrasol, Key-Pred, Cotolone, Depo-Predate, Predicort-50, Predalone 50, Predacort 50, Predate-50, Predaject-50, Pred-Ject-50, Key-Pred SP, Medicort, Predicort RP, Pri-Cortin 50, Predcor, Bubbli-Pred, AsmalPred Plus, Flo-Pred Oral Suspension
Synonyms: Prednisolone, PrednisoLONE (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Digoxin Injection-Prednisolone Syrup
- Digoxin Injection-Prednisolone Tablets
- Digoxin Injection-Prednisone
- Digoxin Injection-Prednisone Delayed-Release Tablets
- Digoxin Injection-Prednisone Intensol
- Digoxin Injection-Prednisone Oral Concentrate
- Prednisolone Sodium Phosphate Oral Solution-Digoxin Intravenous
- Prednisolone Sodium Phosphate Oral Solution-Digoxin Oral Solution
- Prednisolone Sodium Phosphate Oral Solution-Digoxin oral/injection
- Prednisolone Sodium Phosphate Oral Solution-Digoxin Tablets
- Prednisolone Sodium Phosphate Oral Solution-Dihydro CP Syrup
- Prednisolone Sodium Phosphate Oral Solution-Dihydrocodeine BPM Phenyleph HCl