Divalproex and Rifadin IV Intravenous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using rifAMPin together with divalproex sodium may decrease the effects of divalproex sodium. Contact your doctor if your condition changes or if you experience a loss of seizure control. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Rifampin may significantly increase the oral clearance of valproate resulting in reduced plasma concentrations. Clearance of single valproate doses increased by 40% in healthy subjects when given after 5 days of rifampin administration. The exact mechanism of interaction has not been established, but induction of valproate metabolism by rifampin is suspected.

MANAGEMENT: Monitoring for altered efficacy is recommended. Patients should be advised to notify their physician if they experience a loss of seizure control or other signs of reduced efficacy. Dosage adjustments may be required if an interaction is suspected.

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?

Rifadin IV Intravenous

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: Rifadin IV (Intravenous), Rifadin IV

What is Rifadin IV Intravenous?