Duvelisib and Sudafed PE Cold & Cough Child
Determining the interaction of Duvelisib and Sudafed PE Cold & Cough Child and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Duvelisib may increase the blood levels and effects of dextromethorphan. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with duvelisib may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The mechanism is reduced clearance due to inhibition of CYP450 3A4 by duvelisib. The interaction may be particularly important for sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index. When a single 2 mg oral dose of midazolam, a sensitive CYP450 3A4 substrate, was administered to 14 healthy adult study subjects following multiple doses of duvelisib 25 mg twice daily for 5 days, midazolam peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 2.2- and 4.3-fold, respectively.
MANAGEMENT: Caution is advised if duvelisib is used in combination with sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index (e.g., ergot alkaloids, colchicine, fentanyl, macrolide immunosuppressants, midazolam, triazolam, vinca alkaloids). Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever duvelisib is added to or withdrawn from therapy.
- "Product Information. Copiktra (duvelisib)." Verastem, Inc., Needham, MA.
Generic Name: dextromethorphan / phenylephrine
Brand name: Children's Triacting Daytime, PediaCare Children's Multi-Symptom Cold, Safetussin CD, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Albatussin Pediatric, Pedia Care Multi-Symptom Cold, PediaCare Childrenâs Multi-Symptom, Sudafed PE Cold & Cough Child, Triacting Day Time Cold/Cough, Vicks Formula 44D Cough & Sinus Congestion Relief, Triaminic Daytime Cough & Cold, Triaminic Thin Strips Cough and Congestion, Triaminic Toddler Cough and Cold Thin Strips, Dimetapp Cold & Cough, Triaminic Thin Strips Infant Decongestant Plus Cough, PediaCare Infant Decongestant & Cough
Synonyms: Sudafed PE Children's Cold & Cough
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Duvelisib-Sudafed PE Head Congestion
- Duvelisib-Sudafed PE Non-Drying Sinus
- Duvelisib-Sudafed PE Pressure + Pain
- Duvelisib-Sudafed PE Pressure+Pain+Cold
- Duvelisib-Sudafed PE Pressure+Pain+Cough
- Duvelisib-Sudafed PE Severe Cold
- Sudafed PE Cold & Cough Child-Duvoid
- Sudafed PE Cold & Cough Child-Duzallo
- Sudafed PE Cold & Cough Child-Dvorah
- Sudafed PE Cold & Cough Child-DX1 OraGenomic Medicated DNA
- Sudafed PE Cold & Cough Child-DX2 OraGenomic Medicated DNA
- Sudafed PE Cold & Cough Child-Dxevo Tablets