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Dymista and PCE Dispertab

Determining the interaction of Dymista and PCE Dispertab and the possibility of their joint administration.

Check result:

Dymista <> PCE Dispertab

Relevance: 09.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with erythromycin, a moderately potent CYP450 3A4 inhibitor, does not appear to significantly alter the systemic exposure to fluticasone following intranasal administration or oral inhalation. Fluticasone undergoes extensive first-pass and systemic metabolism via hepatic and intestinal CYP450 3A4, and inhibition of the isoenzyme by potent inhibitors such as ritonavir and ketoconazole has been shown to increase systemic bioavailability of the drug. However, a clinically significant interaction with erythromycin has not been reported. In a multiple-dose drug interaction study, coadministration of fluticasone nasal spray twice daily and erythromycin 500 mg twice daily did not affect fluticasone levels, but reduced plasma cortisol levels by 2%. Similary, coadministration of orally inhaled fluticasone propionate (500 mcg twice daily) and erythromycin (333 mg three times daily) did not affect fluticasone propionate pharmacokinetics. No particular precaution should be necessary during concomitant use.

References

"Product Information. Flovent (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Flonase (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Veramyst (fluticasone nasal)." GlaxoSmithKline, Research Triangle Park, NC.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Dymista

Generic Name: azelastine / fluticasone nasal

Brand name: Dymista

Synonyms: Dymista Nasal Spray

What is Dymista?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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