Gengraf Capsules and Uroxatral

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CycloSPORINE may increase the blood levels of alfuzosin. This can cause blood pressure to fall excessively and heart rate to increase, especially when you rise from a sitting or lying position. The risk of other side effects such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) may also increase. Let your doctor know if you develop these symptoms while using alfuzosin and they do not go away on their own or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medication affects you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with moderate inhibitors of CYP450 3A4 may increase the plasma concentrations of alfuzosin, which is primarily metabolized by the isoenzyme. Hypotension, syncope, QT prolongation, and priapism may occur. In one study, repeated oral administration of 240 mg/day of diltiazem, a moderate CYP450 3A4 inhibitor, with 7.5 mg/day (2.5 mg three times daily) of alfuzosin increased alfuzosin peak plasma concentration (Cmax) and systemic exposure (AUC) by 50% and 30%, respectively, and increased diltiazem Cmax and AUC each by 40%. No changes in blood pressure were observed in this study.

MANAGEMENT: Caution is advised if alfuzosin is prescribed in combination with moderate CYP450 3A4 inhibitors. Pharmacologic response to alfuzosin should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy, and the alfuzosin dosage adjusted as necessary. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, orthostasis, syncope, or tachycardia. Taking alfuzosin at bedtime may minimize the occurrence of orthostatic effects. Patients should also avoid driving or operating hazardous machinery until they know how the medication affects them.

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Uroxatral

Generic Name: alfuzosin

Brand name: Uroxatral

Synonyms: n.a.

What is Uroxatral?